Research, Education & Service Development

The ICMS is research active with numerous trials currently on going between the two Trusts. Collaboration is a key value of the ICMS. If you wish to find out more about collaborating with us, please email

Selected Highy Cited ICMS Publications 2012-2018*

Das, M., Loveday, J.J., Wynn, G.J., Gomes, S., Saeed, Y., Bonnett, L.J., ... Gupta, D.  (2017). Ablation index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values. EP: Europace. 19(5): 775-783. doi: 10.1093/europace/euw105. Cited by 53.

Wynn, G.J, Panikker, S., Morgan, M., Hall, M., Waktare, J., Markides, V., ... Gupta, D. (2016). Biatrial linear ablation in sustained nonpermanent AF: Results of the substrate modification with ablation and antiarrhythmic drugs in nonpermanent atrial fibrillation (SMAN-PAF) trial. Heart Rhythm. 13(2): 399-406. doi: 10.1016/j.hrthm.2015.10.006. Epub 2015 Oct 9. Cited by 21.

Wynn, G.J., El-Kadri, M., Haq, I., Das, M., Modi, S., Snowdon, R., ... Gupta, D. (2016). Long-term outcomes after ablation of persistent atrial fibrillation: An observational study over 6 years. Open Heart. 3(2). Cited by 16.

Das, M., Wynn, G.J., Morgan, M., Lodge, B., Waktare, J.E.P., Todd, D.M., ... Gupta, D. (2015). Recurrence of atrial tachyarrhythmia during the second month of the blanking period is associated with more extensive pulmonary vein reconnection at repeat electrophysiology study. Circ: Arrhythm Electrophysiol. 8(4): 846-852. Cited by 25.

Jarman, J.W.E., Panikker, S., Das, M., Wynn, G.J., Ullah, W., Kontogeorgis, A., ... Wong, T. (2015). Relationship between contact force sensing technology and medium-term outcome of atrial fibrillation ablation: a multicenter study of 600 patients. J Cardiovasc Electrophysiol. 26(4): 378-384. doi: 10.1111/jce.12606. Cited by 50.

Morgan, J.M., Kitt, S., Gill, J., McComb, J.M., Ng, G.A., Raftery, J., Roderick, P., Seed, A., Williams, S.G., Witte, K.K., Wright, D.J., Harris, S., Cowie, M.R. (2017). Remote management of heart failure using implantable electronic devices. Eur Heart J. 38(30): 2352-2360. doi: 10.1093/eurheartj/ehx227. Cited by 47.

Randles, D.A, Hawkins, N.M., Shaw, M., Patwala, A.Y., Pettit, S.J., Wright, D.J. (2015). How many patients fulfil the surface electrocardiogram criteria for subcutaneous implantable cardioverter-defibrillator implantation? Europace. 16(7): 1015-1021. doi: 10.1093/europace/eut370. Cited by 61.

Raphael, C.E., Cooper, R., Parker, K.H., Collinson, J., Vassiliou, V., Pennell, D.J., de Silva, R., Hsu, L.Y., Greve, A.M., Nijjer, S., Broyd, C., Ali, A., Keegan, J., Francis, D.P., Davies, J.E., Hughes, A.D., Arai, A., Frenneaux, M., Stables, R.H., Di Mario, C., Prasad, S.K. (2016). Mechanisms of myocardial ischemia in hypertrophic cardiomyopathy: Insights from wave intensity analysis and magnetic resonance. J Am Coll Cardiol. 68(15): 1651-1660. Cited by 21. 

Cooper, R.M,, Shahzad, A., Hasleton, J., Digiovanni, J., Hall, M.C., Todd, D.M., Modi, S., Stables, R.H. (2015). Radiofrequency ablation of the interventricular septum to treat outflow tract gradients in hypertrophic obstructive cardiomyopathy: A novel use of CARTOSound® technology to guide ablation. Europace. 18: 113-120. Cited by 15. 

Vidal-Petiot, E., Ford, I., Greenlaw, N., Ferrari, R., Fox, K. M., Tardif, J.C., ... Steg, P. G.(2016). Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: An international cohort study. Lancet. 388(10056): 2142-2152. doi:10.1016/S0140-6736(16)31326-5. Cited by 168.

Fox, K., Ford, I., Steg, P. G., Tardif, J.C., Tendera, M., & Ferrari, R. (2014). Ivabradine in stable coronary artery disease without clinical heart failure. N Engl J Med. 371(12): 1091-1099. doi:10.1056/NEJMoa1406430. Cited by 359.

Shahzad, A., Kemp, I., Mars, C., Wilson, K., Roome, C., Cooper, R., ... Stables, R.H. (2014). Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): An open-label, single centre, randomised controlled trial. Lancet. 384 (9957): 1849-1858. doi: 10.1016/S0140-6736(14)60924-7. Cited by 455.

Steg, P.G., Greenlaw, N., Tendera, M., Tardif, J. -C., Ferrari, R., Al-Zaibag, M., ... Fox, K. M. (2014). Prevalence of  anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease data from the international observational CLARIFY registry. JAMA Intern Med. 174(10): 1651-1659. doi:10.1001/jamainternmed.2014.3773. Cited by 48. 

Fox, K., Komajda, M., Ford, I., Robertson, M., Boehm, M., Borer, J. S., .Steg, P.G., .. Swedberg, K. (2013). Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials. Eur Heart J. 34(29): 2263-2270. doi:10.1093/eurheartj/eht101. Cited by 74.

Steg, P.G., Greenlaw, N., Tardif, J.C., Tendera, M., Ford, I., Kaeaeb, S., Abergel, H., Fox, K.M., Ferrari, R. (2012). Women and men with stable coronary artery disease have similar clinical outcomes: insights from the international prospective CLARIFY registry. Eur Heart J. 33(22): 2831-2840. doi:10.1093/eurheartj/ehs289. Cited by 143.

*up to 5 peer review original papers per faculty member with at least 15 citations per article.

Current research within the ICMS is broken down into five main research groups:


Cardio-oncology is led by Dr Jay Wright , Consultant Cardiologist (LHCH).
Presently the RBH and LHCH provide cardiology services to cancer patients with cardiac problems. We aim to insure that both services utilise shared protocols and procedures.


Research projects into mechanistic evaluation and preventative treatments are under way. Strategic guidance from Professor Karl Swedberg (Institute of Medicine, University of Gothenberg) enables us to focus on key areas of contemporary disease management.

Education and Service Development

Presently the RBH and LHCH provide cardiology services to cancer patients with cardiac problems. We aim to ensure that both services utilise shared protocols and procedures.

Inherited Cardiac Conditions (ICC) and Imaging

ICC and imaging is led by Dr Rob Cooper (LHCH).
The group is active within the areas of research, education and service development. The ICC and imaging group is supported by Dr Deborah Morris-Rosendahl who is a consultant clinical scientist and head of the clinical genetics and genomics laboratory at the Royal Brompton Hospital.


Currently all cardiac testing is done at the genetics lab located at RBH and therefore facilitating research collaborations. Additionally, Dr Tim Fairbairn has recently been accepted onto the NIHR Research Scholars Programme to facilitate further research.

Education and Service Development

The ICC and Imaging group are currently working on developing a collaborative database between the two Trust in order to facilitate service development and research. The ICMS has also enabled staff exchanges between the two trusts. The programmes proved so valuable that we have now established a continuous program for staff exchange visits for all professional groups.

Interventional Cardiology

Interventional Cardiology is led by Professor Rod Stables , Consultant Cardiologist (LHCH), with academic support from Dr Patrick Serruys, Professor of Interventional Cardiology (Thoraxcentre, Erasmus University, Rotterdam).


Interventional cardiology is working to improve education and clinical services at both Trusts alongside developing research projects. Through the ICMS collaboration the findings from the HEAT-PPCI trial were published in the Lancet informing practice throughout the world and promoted a change in the guidelines for PCI revascularisation by the European College of Cardiology. Professor Kim Fox (Head of the National Heart and Lung Institute, Imperial College) and Professor Gabriel Steg (Universite Paris-Diderot and the National Heart and Lung Institute, Imperial College) provide guidance on key areas of research.

Education and Service Development

Staff at both Trusts joined forces to share the product of independent projects to create a patient safety checklist (akin to the WHO safe surgery checklist) designed for the cath lab environment. A version has now been endorsed by the British Cardiovascular Society as a national standard.


Devices is led by Dr Mark Mason , Consultant Cardiologist (RBHT) alongside Dr Jay Wright (LHCH).


We are active across many areas of research, innovative health, care delivery and education. A strong background of basic science and translational research through the NIHR Cardiovascular Biomedical Research Unit at RBHT combined with the disease prevalence and large pacing device service at LHCH enables us to recruit to a diverse range of studies.

The ICMS sites have been awarded a grant of over £1.2 million by NIHR to run a prospective randomised study, CASA-AF, comparing the results of catheter ablation and surgical ablation for patients with long standing persistent atrial fibrillation. This study has recently finished recruitment with the results being available in Autumn 2019. To find out more about the trial, click here .

Education and Service Development

Presently RBHT and LHCH provide cardiology services to cancer patients with cardiac pacing problems. We aim to ensure that both services utilise shared protocols and procedures facilitated through staff exchanges and training.

Adult Congenital Heart Disease (ACHD)

The ACHD group is led by Dr Sonya Babu-Narayan (RBHT).


ACHD is a relatively new area for the ICMS with the development of the ACHD service in Liverpool and therefore research projects will establish themselves as the Liverpool service advances.

Education and Service Development

With the development of the ACHD service in Liverpool and a well-established service at RBHT, the group will work together on both service development and education in the first instance. This includes both staff exchange programmes and training across the sites.

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